Publications and reports
Mental Health Research for Innovation Centre Progress Report | September 2023


We are pleased to present this in-year progress report for the Mental Health Research for Innovation Centre. Throughout this report we will refer to our Centre as M-RIC. This report provides an overview of who we are, and what we have accomplished during the first nine months of establishment along with a sneak peak of what’s ahead. It covers the time frame January to September 2023.

Going forward, it is our intention to produce a full annual report in spring each year (with effect from spring 2024, in line with our funder’s requirements).

A glossary of terms explaining technical language can be found at the end of this report.

Acknowledgements: We would like to extend our gratitude to the National Institute for Health and Care Research (NIHR) and the Office for Life Sciences (OLS) who act together as our funders. We also want to thank our colleagues across Mersey Care NHS Foundation Trust and the University of Liverpool for their input and assistance in producing this report. These include, but are not limited to, our patient and public advisors, our M-RIC Co-Directors, our M-RIC management team, our work package lead investigators and their co-investigators, our Patient and Public Involvement and Engagement (PPIE) leads, our communications leads, and our finance and human resources colleagues.


  • Professor Nicola Wilson – M-RIC Programme Director, Mersey Care NHS Foundation Trust,
  • Dr Claire Smith – M-RIC Head of Operations (Research programmes), The University of Liverpool
  • Prof Iain Buchan, M-RIC Co-Director, The University of Liverpool
  • Prof Nusrat Husain, M-RIC Co-Director, Mersey Care NHS Foundation Trust

Exceeding our targets: key headlines

We are delighted to report that we have exceeded our year one targets, establishing M-RIC promptly through extraordinary efforts.

During the first nine months we count amongst our accomplishments:

31 posts recruited

16 industry partners

12 funding proposals submitted

33 service users engaged in grant applications

Approximately 1M patient records available


Our aim

To improve mental healthcare for all patients and service users. We will do this by making Liverpool a world leader in better mental healthcare from research embedded in care.

What is M-RIC?

M-RIC has been funded £10.5 million from the Office for Life Sciences (OLS) and the National Institute for Health and Care Research (NIHR). It is part of the Government’s UK Mental Health Mission announced within His Majesty’s Treasury’s Life Sciences Growth Package on 26 May 2023. The UK Mental Health Mission aims to accelerate mental health research through a UK network of leading investigators – the NIHR Mental Health Translational Research Collaboration (MH-TRC), which we are proud to be part of.

M-RIC is at its heart a partnership between Mersey Care NHS Foundation Trust and the University of Liverpool. Our aim is simple, to improve mental healthcare for all patients and service users, and our ultimate objective is making Liverpool a world leader in better mental healthcare from research embedded in care.

The input of our patients, service users, their carers, and families is embedded in our work as co-production ensures their life experiences shape our activity. That’s why we are also working side-by-side with industry to reimagine the ways in which serious mental illness is treated and managed for generations to come.

The pandemic and cost of living crisis have only widened health inequalities for our community and seen a stark rise in mental health conditions and demand on mental health services, and the distribution of funding for mental health research is an inequality in of itself. We are leading out of Liverpool to address this head on.

Leading out of Liverpool

Liverpool’s clinical and academic expertise is strong in translating research into results that directly benefit our patients and service users. 21st Century science and technology advances – in pharmaceutical, behavioural, and digital therapies – will benefit our communities, who are economically disadvantaged but rich in lived experiences.

The impact of mental health in numbers

  • It is estimated that the impact of mental ill health costs the national economy £118 billion per year. [1]
  • In 2019, there were 10.3 million recorded instances of mental ill-health over a 12-month period and the third most common cause of disability was depression. [1]
  • The cost to employers of mental health related sickness absence in 2020-21 was £56 billion. (2)

Liverpool City Region has one of the UK’s highest burdens of socio-economic disadvantage and poor mental health, with mental health service users traditionally facing a life expectancy 20 years less than the UK average.



Our approach

Working side-by-side

Fundamental to M-RIC’s objectives is working side-by-side with our community – in a three-way relationship between patients and service users, researchers, and mental health professionals. We will give equal involvement in co-design to people in our communities who could benefit from our research. Our industry partners also work alongside us to facilitate and accelerate the adoption of innovations within our research projects and new services and treatment options.

Sustainability planning

Our respective organisations have been clear in our ambition and vision to ensure M-RIC’s financial sustainability beyond the five-year duration of the funding award from the NIHR and the OLS to establish M-RIC. This sustainability planning and futureproofing has been core to M-RIC from the outset, and our sustainability strategy is well underway.

Domains of activity

Through establishing M-RIC, we have created the infrastructure necessary to bring together academic researchers, NHS staff, patients and public, and our Industry partners to develop and evaluate new treatments and deliver innovative services.

This includes:

  • new ways of analysing patterns within patient data to improve our understanding and treatment of certain mental health conditions
  • trying out new uses of existing medications
  • researching digital therapies such as apps and artificial intelligence, as ways to support mental wellbeing.

Put simply, this means we can improve mental healthcare by shortening the time it takes for our research to deliver real benefits for our community.

M-RIC Domains of activity

Our approach focuses upon four domains of activity

  • Patient and Public Involvement and Engagement (PPIE)
  • Research delivery
  • Centre governance and infrastructure
  • Capacity and capability building

Approach to delivery

Our research delivery revolves around six research areas we call “work packages” . Each work package has designated clinical academic leadership supported by researchers and PPIE advisors from our respective organisations, and our industry partners. We expand upon work already underway across our work packages below.

We have created a robust system of Centre governance and infrastructure. M-RIC’s governance framework is illustrated below. It ensures that we are providing assurance and performance reporting to not only our respective organisations but also our funders and stakeholders.

Through what we call our capacity and capability building activity, we are substantially increasing our NHS and academic joint workforce through increased numbers of investigators and mentoring and developing fledgeling and early-career researchers.

For our research to have a real impact on future NHS mental healthcare, we need the involvement and insight of patients, service users, carers, family members and the wider public. Our PPIE team ensures that service users’ lived experiences are embedded in our work packages. Our PPIE activity will facilitate collaborative working between patients, members of the public, researchers and healthcare professionals with the aim of improving the outcomes of our research.

M-RIC Governance

M-RIC has an established structure of governance; providing assurance and oversight of what we do for all our stakeholders – our patients, service-users, their families, our respective organisations, our funding organisations, our industry partners, and our civic partners.

Ultimate oversight lies with our Steering Group, which is comprised of M-RIC staff who are responsible for delivery. During the early-stage of Centre set up, the Steering Group meets monthly to monitor progress against our objectives and assess any risks to progress against our objectives.

Reporting directly to the Steering Group is the Core Investigators’ Group. The Core Investigators’ Group is comprised of senior researchers who are responsible for the delivery of research within our defined work packages. The Core Investigators meet monthly.

Our Steering Group and Core Investigators’ Group have two-way communication with our funding organisations and the national UK Mental Health Mission.

Reporting directly to the Core Investigators’ Group are two further governance groups. Firstly, the Data Governance Group which is comprised of senior data and digital researchers responsible for the safe management and use of how we use data in our research. Secondly, the Centre Operations Group (COG) which is comprised of operational staff whose sole aim is to support the effective delivery of our activity and research. Think of the Centre Operations Group as the engine room!

M-RIC Governance structure

The image shows a diagram of the M-RIC Governance structure. An M-RIC Steering Group is shown at the top of the diagram. The steering group works with new commercial partners and is fed into by a Core Investigators Group. The Core Investigators Group is fed into by a Data Governance Group and a Centre Operational Group. Beneath this are the six research work packages and then capacity building and patient and public involvement and engagement. The Steering Group and Core Investigators Group also work with the International Advisory Group, the National Institute for Health and Care Research, Office for Life Sciences and The NIHR Mental Health Translational Research Collaboration.


Data and digital infrastructure

Work package one: Combined Intelligence for Translational Health Research (CIX)

Industry partners: Microsoft, PA Consulting, Holmusk, Pangea, IBM, and Quantexa

Short term (1-2 years) objectives Progress against objectives
Provide Integrated research-ready data

  • Build the CIX data infrastructure initially for 10 workspaces and five trials.
  • Establish CIX information governance standard operating procedures.
  • Deploy CIX in Mersey Care NHS Foundation Trust with Microsoft to NHS England Trusted Research Environment (TRE) standards with open-source technologies. This builds on a year’s preparation of a blueprint replicable/networkable across UK mental health services, and with (sub)national NHS data services.
  • Enhance mental health dataflows into Combined Intelligence for Population Health Action (CIPHA) (then CIX for research), including social prescribing, environmental, genomic, imaging and person- captured data (e.g., wearables) closing the action-research loop.
  • Link employment / welfare data in CIPHA/CIX with the Health Foundation

Advance the scale and scope of NHS embedded trial

  • Deploy EMIS-X Analytics linked to CIX to identify/recruit patients from primary care.
  • Extend CIX pilot (currently supporting PAX-D ADEPP and GOTHIC 2 trials) onboarding 5-10 more trials over the first three years.
  • A Trusted Research Environment (TRE) has been created. This provides access for researchers and NHS staff to the right set of data analysis tools without compromising security, and work is currently underway on the first live import of data.
  • M-RIC researchers are working closely with colleagues across Cheshire and Merseyside/North West to link North West data into Combined Intelligence for Population Health Action (CIPHA) data to increase our impact.
  • We are working with Holmusk to use their technology (auto- curation and predictive analytics) to standardise the data and make it easier to analyse with other systems. We are using a Treatment Resistant Depression (TRD) use-case for this test to look for patterns in the data.

Work package 2. Mental Health Avatar

Industry partners: Apple, Concentrix, Blinx Healthcare, and Evergreen Life

Short term (1-2 years) objectives Progress against objectives
Establish Avatar model and dataflows

  • Consolidate and secure partnerships with companies/groups providing apps / interfaces for service-users use over symptoms/other experiences.
  • Publish a model for integrating personalised interaction profiles into care records.
  • Set up at novel test environment, enabling study of “sleep avatars” and hypnograms linked to care pathways.

Develop new insights from Avatar

  • Work with Our Future Health to enhance their interactivity and longitudinal data fidelity and care-record linkage.
  • Partner with regulators to improve the validation of algorithms for personalised interaction.
  • Our Mental Health Avatar project is well underway to improve how data is collected, processed, and linked to electronic care records – then used in near real time – to benefit treatments for patients.
  • The ESNTL Wellness pilot trial, in partnership with Apple and Concentrix, is underway, using smart technology (wearables) for Mersey Care NHS Foundation Trust staff to monitor health and wellbeing.
  • Work is also underway in secondary care data to develop models, in collaboration with colleagues in Oxford.
  • Additional NIHR funding has been provided SEISMIC development award: SysteMatic, with the added intention of researchers bidding for a Systems Engineering Centre.
  • Ethics application is in development to allow the collection (with consent) of high-quality data for research re-use, maintained in electronic form.

Work package 3: Innovative Therapies for Mood Disorders

Industry partners: Compass Pathways, Blinx Healthcare, Evergreen Life, LYVALabs

Short term (1-2 years) objectives Progress against objectives
Advance trials

  • Establish “consent-to-contact” cohorts on CIX for pharmacological, psychological, digital and medical device trials in depression prevention, difficult to treat depression (DTD), treatment resistant depression (TRD).
  • Extend recruitment into trials from non-medical settings such asthe Life Rooms and The Reader.

Fuel innovative services

  • Establish a regional mood disorders treatment centre integrating primary and secondary care management of mood disorders and routine seeking of “consent-to-contact”.
  • Pursue rapid innovations through CYP2D6/CYP2C19 polymorphism information informing DTD/TRD therapies/pathways.
  • A mechanism of data navigation is underway to identify those patients most in need of innovative methods to help people with difficult to treat depression.
  • An integrated mood disorder service pathway – one of the first in the UK – is in the set-up phase. This will act as a ‘follow on’ assessment service, and a multi-disciplinary (psychiatry, psychology, nursing, occupational therapy, dietetics) team of staff is being convened. The first cohort of patients suitable for the service has been identified, and they will collaborate side-by side with our clinical staff and researchers to co-produce/design the service pathway for the benefit of future patients.
  • Other activity revolves around studying the mixed presentation of anxiety and depression, and the implications of taking multiple medications.

Work Package 4: Child and Adolescent Mental Health

Industry Partners: Digital Sparta, My School Designs, and Mind District

Short term (1-2 years) objectives Progress against objectives
Enhance early life brain health discovery

  • Link the Children Growing Up in Liverpool (CGULL) birth cohort study into CIX and TRC research and enhance its mental health data linkage and curation.
  • Enhance digital phenotyping of pregnancy in C-GULL study with work package 4 and

Co-produce and evaluate digital interventions

  • LIFE (Life skills For Everyone): Develop and feasibility test web- based dialectical behavioural therapy for children and young people experiencing emotional distress and difficulties with emotional regulation.
  • Mindset Sketchpad: Hone and evaluate an existing web-based positive psychology intervention to understand its effectiveness in UK school and community settings.
  • Our researchers are working with adolescents in trialling MindAR (therapeutic game and speech biomarkers). The mechanisms of age-appropriate involvement for our younger age group of patients and service users not only in the way in which we undertake our trials within this work package, but also their input into co-design, is fundamental.
  • CAMHS digital health is a theme in the Global Mental Health programme, and work is already underway to reverse translate some of those principles into M-RIC’s context, more specifically with service and clinic providers within Mersey Care NHS Foundation Trust.
  • Our researchers are developing an application which reviews a predictive tool to assist clinicians in mental health interventions at the right level in perinatal women, which can subsequently impact a child’s or adolescent’s mental health. The CGULL birth cohort study, as a triad design, is ideally placed to potentially validate the predictive tool.

Work Package 5: Neuroimmune Therapeutics for Psychosis

Short term (1-2 years) objectives Progress against objectives
Deliver a platform for neuroimmune therapeutics in psychosis

  • Build capability by training clinicians in delivering proof of concept (PoC) studies (via the TRC).
  • Use CIX to identify well-characterised patients and seek “consent-to-contact” for studies from 6 Early Intervention Services.

Identify and use novel biomarkers and phenotypes

  • Contribute blood for whole exome sequencing and genome-wide genotyping (with NIH/Regeneron study led by Walters (TRC: EP).
  • We are creating an infrastructure for innovative immune therapies for schizophrenia by co-designing a feasibility study with patients whose symptoms persist despite treatment and with a developing first-instance psychosis PPIE Group.
  • We aim to test novel ideas about the role of the cellular immune system in psychosis and will be profiling immune cell populations with Prof Lance Turtle at the Institute of Immunology in the feasibility study.
  • Our group are defining neuro-degenerative biomarkers which may relate to immune changes. We collaborate with patients and research teams in Birmingham and Oxford in related studies.
  • Common factors between work package 5 and work package 1 are emerging to deploy CIX to assist in the identification of potential participants and identify impacts of general health and wellbeing.

Work Package 6: System-Wide Mental Health Discovery and Implementation

Industry Partners: Quantexa and EMIS

Short term (1-2 years) objectives Progress against objectives
Embed M-RIC/TRC in health system policies – combining clinical and public health approaches

  • Link MHM/TRC to the Faculty of Public Health’s Public Mental Health taskforce.

Unify primary and secondary care mental health research and service improvement in a population health management programme to build a ‘mental health learning system’

  • Co-create with patients and clinicians an approach to clinical trials that improves recruitment and participant experience from general practices or via apps.
  • Build CIPHA dashboards to help clinicians understand mental health recording and clinical coding variations to improve data quality.
  • Work to link civic and mental health data to examine impact onservice use, is well underway.
  • A telehealth programme bid has been submitted.
  • Following a recent Adverse Childhood Experiences (ACEs) conference, our researchers are considering the development of a Liverpool ACEs Group focused upon developing resilience.
  • A workshop on 29 August brought together work package 6 researchers to plan out the long-term approach. Work focussing on mental health policy, hope and mattering, social prescribing and physical activity, polypharmacy, trauma and ACEs are being explored.
  • Our researchers have met with regional PPIE leads from North West Applied Research Collaborative (ARC) and Civic Data Cooperative (CDC) to discuss aligned work and how resources might be pooled across our different work packages.

Centre governance and infrastructure

Short term (1-2 years) objectives Progress against objectives
Recruit staff, agree the scope of work, map key partnerships, and establish the governance framework.

  • Recruitment of core personnel in line with equality, diversity, andinclusion policies.
  • M-RIC governance structure defined and implemented (board; steering group; management and operations groups with terms of reference and associated oversight structures in place).
  • Multi-sector collaborations with stakeholders built upon including cross-MH TRC synergies) evidenced by stakeholder mapping, onboarding processes, new partners documented and contracting model agreed.
  • Centre wide monitoring and evaluation framework defined and operational, feeding into national reporting mechanisms. Evidenced by progress reports, baseline and ongoing metrics recorded, theory of change defined and reviewed.
  • Internal/external communication strategy developed.
  • We have worked swiftly and agilely, and M-RIC is fully operational.
  • We have firmly established our identity throughout Liverpool and beyond! Our dynamic, interactive presence is evident on X/Twitter and LinkedIn, and we have launched M-RIC’s dedicated website.
  • We have met our year 1 target of recruiting research and operational expertise across a variety of disciplines. This includes specialist HR, finance, communications, contracts, and project management staff.
  • We have demonstrated spend to profile for Q4 of Fiscal Year 22/23 and Quarter 1 of Fiscal Year 23/24.
  • We have set up robust contractual agreements with third parties and Industry partners.
  • We have created a framework of governance for M-RIC which meets the complex assurance needs of a trans-organisation, and cross-sector environment.
  • We formally announced M-RIC on 26 May 2023, bringing to life a cross-organisation communications plan.

Capacity and Capability Building

Short term (1-2 years) objectives Progress against objectives
Embed a strategic plan for Interdisciplinary, multi-organisation mental health research training and development

  • Clinical research capacity building programme developed with support of the MH TRC capacity building theme.
  • In alignment with the UK Mental Health Mission, we are taking seriously our commitment to future-proofing the research and innovation workforce of the future by nurturing and encouraging our home-grown talent.
  • We are well underway in the process of undertaking a scoping exercise aimed at capturing how involvement – ranging from support to frontline delivery – of research and clinical trials varies across not only the spectrum of professional development but also the healthcare professions at Mersey Care NHS Foundation Trust.
  • Through close alignment with the NIHR Mental Health Translational Research Collaboration (MH TRC) Capacity Theme, we are building further capacity and have already created 30+ honorary posts and secondments, including academic clinical fellows, to achieve a critical mass of clinical research at Mersey Care NHS Foundation Trust.
  • Discussions are taking place with the Capacity and Capability Lead for the UK Mental Health Mission to build a short, 3-day certificate training programme for peer researchers who will provide valuable input into the way in which service user feedback is captured to ensure ongoing contribution and co-design and build a wider group of peer/lived experience advisors.

Patient and public involvement and engagement

Short term (1-2 years) objectives Progress against objectives
Create the PPIE process

  • Establish an expert group of service users and public advisors to assess performance against our Equality, Diversity and Inclusion (EDI) commitments.
  • PPIE strategy established to complement existing Liverpool and TRC structures with the first phase of engagement, and training operation.
  • Monitor local community representation/engagement by
    • increased numbers of service-users trained and attending
    • co-production workshops and meetings.
  • Take a multi-experience, life-course approach to reflect place-basedclusters of mental health risks and experiences across age groups.
  • Invest in civic, system-wide communications (co-created with service-users) to highlight M-RIC’s ambitions and activities.
  • PPIE Strategy and Engagement Delivery Plan has been drafted and circulated internally.
  • The PPIE service-user role descriptions are completed, and patient recruitment frames of reference are in development via co- production with service users.Our PPIE partnership networking has commenced:
  • Partnerships established with PPIE leads at Mersey Care NHS Foundation Trust and the University of Liverpool.
  • We attended Mersey Care Service Evaluation showcase.
  • Introductory meetings held with PPIE teams – ARC NW / Mersey Care.Our service user co-production involvement has commenced:
  • We held our first introductory workshop for service users in June 2023.
  • We have held three PPIE preparatory meetings with key service user representatives.
  • We have engaged with third sector organisations with diverse populations such as Mary Seacole House, African Caribbean Centre, the Black Women’s Health Network, and the Walton and Southport Life Rooms.
  • We are currently co-producing a workshop with participant service users for World Mental Health Day (10.10.23)

Further information can be found below.

Reaching out

The Introduction to M-RIC service user workshop (29.6.23) involved 16 service users in the development of our PPIE strategy development and delivery planning.

Other outreach activities include:

  • Engagement with local third sector organisations with diverse populations such as Mary Seacole House, African Caribbean Centre and the Black Women’s Health Network.
  • Engagement with third sector organisations and groups active in the health and wellbeing sector: Walton and Southport Life Rooms, the Brink Liverpool, Kensington Vision, and Liverpool radio stations.
  • Developing annual calendar of partner and third sector events and annual general meetings to attend and brief members on M-RIC progress, e.g., Mersey Care NHS Foundation Trust’s Annual General Meeting (AGM) in September 2023.
  • Planning attendance at public events including Blackfest 2023, Black History Month, and World Mental Health events.
  • As well as developing our mental health networks, we are also developing a library of UK good practice in PPIE standards, including NIHR and Applied Research Collaboration North West Coast (ARC NWC) resources.

M-RIC's first public workshop in June 2023M-RIC's first public workshop in June 2023


Delivering the national mission

On 15 June we hosted a visit from Professor Kathryn Abel and Professor Husseini Manji, the Co-Chairs of the UK Mental Health Mission, along with colleagues from NIHR and Office for Life Sciences, to officially launch the UK Mental Health Mission – from Liverpool.

Photo of Prof Tim Jones (Vice-Chancellor, University of Liverpool), Prof Nusrat Hussain (Global Research Director, Mersey Care), Prof Kathryn Abel (National UK Mental Health Mission Co-Chair), Prof Husseini Manji (National UK Mental Health Mission Co-Chair), Prof Joe Rafferty CBE, (Chief Executive, Mersey Care) and Prof Iain Buchan (Chair in Public Health and Clinical Informatics, University of Liverpool).

UK Mental Health Mission Co-Chairs Kathryn Abel and Husseini Manji said:

We’re delighted to visit Liverpool and hear directly from the University of Liverpool and Mersey Care NHS Foundation Trust about their plans for the new Mental Health Research for Innovation Centre, funded as part of the UK Mental Health Mission.

We’re working together to make the new Mental Health Mission a truly revolutionary force behind mental health research. We want the Mission to create tangible differences to the lives of patients in Liverpool, across the UK and internationally.

Bringing together the public sector, patients and industry as equal partners, the Mission will work with the Office for Life Sciences and the National Institute for Health and Care Research (NIHR) to support the NHS and NIHR to capitalise on its size and scope, and on the depth of its data resources. Alongside additional investment in mental health research and infrastructure, the Mission will foster a step change in the way we think about mental health, mental illness and its treatment. This will support development of the critically needed treatments across the spectrum of mental illness.

Next in 2023

Welcoming Professor Lucy Chappell, Chief Executive of NIHR, to Liverpool to formally open M-RIC’s HQ at Liverpool Science Park on 8 December.

Utilising our secure data environment to understand system-wide treatment of the most severe forms of depression and multi-medication management.

Finalising our patient and public involvement and engagement plan, making ready for sign off with our system-wide stakeholders, especially our service user representatives.

Progressing M-RIC’s long-term sustainability plan with actual and potential co-investors from Industry, the NHS and other public services, academia and philanthropists.


The first nine months of M-RIC have been dynamic and productive.

The accomplishments achieved are a testament to the partnership between our two organisations and provide a solid foundation for the upcoming phases as we see out Year One.

We thank NIHR, OLS, our industry partners and our MH- TRC colleagues across the UK for your support and guidance throughout this exciting, critical time.

Please contact us if you have any questions at [email protected].

Glossary of terms

Term Description
The Office for Life Sciences (OLS) A department of UK Government, closely linked to the Department of Health and Social Care.
The National Institute for Health & Care Research (NIHR) The National Institute for Health and Care Research is the UK Government’s major funder of research. With a budget of over £1.2 billion in 2020–21, its mission is to “improve the health and wealth of the nation through research”.
NIHR Mental Health Translational Research Collaboration (MH-TRC) A network of world-class mental health research facilities with the objective of transforming the lives of those affected by mental ill health.
Combined Intelligence for Population Health Action (CIPHA) CIPHA a population health management platform for health data in Cheshire and Merseyside. CIPHA and LCR CDC work together to set up trustworthy research environments for data sharing.
Combined Intelligence for Translational Health Research (CIX) CIX is the data, analytics and trials’ management environment that will enable M-RIC to deliver a mental health learning system at civic scale. CIX builds upon existing infrastructure for research to avoid duplication of effort, improve opportunities for service users to participate in trials and provide quicker turnaround-times for industry partners.
Trusted Research Environment (TRE) TREs provide approved researchers with a single location to access valuable datasets. The data and analytical tools are all in one place, a bit like a secure reference library. It makes research efficient, collaborative and cost effective, providing rich data that enables deep insights which will go on to improve healthcare and save lives.
Treatment Resistant Depression (TRD) Describes the situation when a medication treatment or psychological intervention for depression hasn’t seen an improvement in the person’s symptoms. For some people with treatment-resistant depression, standard treatments aren’t enough. They may not help much at all, or their symptoms may improve for a short while, only to return.
SysteMatic SysteMatic is a project funded by NIHR as part of the Systems Engineering Innovation hubs for Multiple long-term Conditions (SEISMIC) scheme, which brings together researchers from the Universities of Liverpool and Glasgow to develop a plan to design and engineer health systems for people living with multiple long-term conditions
Feasibility Study A feasibility study is a “first look” exploration of a proposed project to determine its merits and viability. A feasibility study aims to provide an independent assessment that examines all aspects of a proposed project, including ethical, technical, economic, financial, legal, and environmental considerations.
Exome Sequencing Whole exome sequencing is a type of genetic sequencing – or categorising – increasingly used to help us understand what may be causing symptoms or a disease.
Genotyping Genetics tries to identify which traits are inherited and to explain how these traits are passed from generation to generation. Our genotype defines our complete set of genetic material, and more specifically the variants an individual carries in a particular gene or genetic location which might influence how we become unwell.


Civic Data Cooperative (CDC) The Liverpool City Region Civic Data Cooperative (LCR CDC) is a data governance project funded by the Liverpool City Region Combined Authority (LCRCA) and hosted by the Faculty of Health and Life Sciences at the University of Liverpool. See Civic Data Cooperative website.

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